The concomitant use of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors could cause a rise in methadone plasma concentrations, which could trigger perhaps lethal respiratory melancholy. Additionally, discontinuation of concomitantly made use of cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers may also lead to an increase in m